Wednesday, 29 October 2014

List of Anti-Cancer Drugs of Herbal Origin

Cancer is a process of rapid abnormal division, multiplication and proliferation of cells that could spread from one organ to another by a process known as metastasis. 

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Mainly cancers are of two types;

A benign type of cancer is the one in which cancer or tumor is limited to an organ and does not affect other organs.

Malignant types of cancers are those which undergo the process of metastasis and damage more than one parts of body. Such types of cancers are always difficult to treat as they produce more catastrophic effects.

The treatment of cancer is quite complicated and various anti-cancer drugs are commonly prescribed by oncologists.

Here you find a list of anti-cancer drugs having herbal origin.

No.
Class
Name of drug
Botanical origin
Type of Cancer
1.
Vinca alkaloids
Vincristine
Vinblastine
Catharanthus roseus (Apocynaceae)
Hodgkin’s disease Lymphomas
Carcinoma Breast
Testicular tumors

2.
Taxanes
Paclitaxel
Docetaxel
Taxus brevifolia
(Taxaceae)
Ovarian cancer
Lung carcinoma
Gastric & Cervical cancers
Prostate & colon cancer

3.
Epipodophyllotoxin
Etoposide
Podophyllum hexandrum
(Berberidaceae)
Lung cancer (small cell lung cancer; SCLC)
04
Topotecan
Irinotecan
Camptotheca acuminata (Nyssaceae)
Camptothecin analouges
Ovarian cancers
Colorectal cancer
Cancer of neck & head
Liver cancer

Colchicine
Demecolcine

Cocus cholchicum
Autumnale (Liliaceae)

Chemotherapy
6.
Maytansinoid
Mcytanacine
Maytansine
Maytenus buchananii,
M.Serrata (Celastraceae)
Chemotherapy
7.
Macrocyclic lactones
Bryostatins
Bryozoa Bugula neritina
Under investigation
8.
Quassinoids
Bruceantin brusato
Brucea javanica
(Simarubaceae)
Leukemia
Colon cancer

9.
Curcuma
Curcumin
Curcuma longa
(Zingiberaceae)
Colon cancer
Bladder cancer
Breast cancer
10.
Flavonoids
Vicenin
Orentin
Ocimum sanctum
(Labiatae)
Prostate cancer
11.
Sesquiterpene

Gossypal

Gossypium barbadense
(Gossypiaceae)

Chemotherapy
12.
Ellipticine
Ellipticine
Ochrosia eliptica
(Apocynaceae)
Leukemia

13.
Pthalide isoquinoline
alkaloid
Noscapine
Papaver somniferum
(Papaveraceae)
Prostate cancer
14.
Acetogenins
Acetogenin
Annona species
(Annonaceae)
Chemotherapy


References:

  1. Reason Wilken et al. Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol Cancer. 2011; 10: 12.
  2. Jordan, Mary Ann; Wilson, Leslie (2004). "Microtubules as a target for anticancer drugs". Nature reviews. Cancer 4 (4): 253–65.
  3. Lokesh Dalasanur. Anti-cancer effects of novel flavonoid vicenin-2 as a single agent and in synergistic combination with docetaxel in prostate cancer. Biochem Pharmacol 2011 Nov 23;82(9):1100-9. Epub 2011 Jul 23.
  4. Kamei J (1996). "Role of opioidergic and serotonergic mechanisms in cough and antitussives". Pulmonary pharmacology 9 (5–6): 349–356
  5. Zhou J, Gupta K, Aggarwal S, Aneja R, Chandra R, Panda D, Joshi HC (2003). "Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation". Mol Pharmacol.63(4):799-807.PMID: 12644580
  6. Deane FM. Synthesis and evaluation of novel ellipticines as potential anti-cancer agents. Org Biomol Chem. 2013 Feb 28;11(8):1334-44. doi: 10.1039/c2ob27186a

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